Treatment Effectiveness of Amantadine Against Dengue Virus Infection

Chieh-Cheng Lin 1, Wen-Ching Chen 2

Affiliations expand

• PMID: 27920420
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• PMCID: PMC5158130
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• DOI: 10.12659/AJCR.901014

Free PMC article

Abstract

BACKGROUND About 400 million cases of dengue, a mosquito-borne disease, are reported annually, but no drug is yet available for treatment. In 1988, at Feng Lin Clinic, Taiwan, we encountered about 10,000 cases and tested various drugs before confirming an antiviral effect of amantadine against dengue virus in vitro. After we administered amantadine to patients for 1-2 days, most achieved full remission. None experienced potentially life-threatening dengue hemorrhagic fever or dengue shock syndrome. Herein, we present 34 cases from recent clinical experience that show amantadine's unusual effect against dengue virus infection. CASE REPORT We divided 34 patients with symptoms of dengue fever, confirmed by a screening test, into 3 groups: 6 Category 1 patients received amantadine at onset, 21 Category 2 patients received amantadine within 2-6 days, and 7 Contrast group patients received no amantadine because they visited other clinics or were admitted to a large hospital. When Category 1 patients were treated with amantadine 100 mg 3 times per day, all symptoms dramatically subsided within 1-2 days. In Category 2 patients, most symptoms diminished within 1-2 days after starting the same regimen. In the Contrast group, all symptoms persisted 7 days after onset. White blood cell and platelet counts in Category 1 and 2 patients recovered to normal range, but remained below low normal in the Contrast group. CONCLUSIONS Amantadine is effective and should be given as soon as possible to stop the disease course if dengue fever is confirmed through screening or clinical signs and symptoms. A well-designed larger sample study is warranted to test this effectiveness.

Keywords: Amantadine; Dengue Virus; Treatment Outcome.

Conflict of interest statement

Conflicts of Interest: None declared

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References

1. 1. Centers for Disease Control and Prevention Dengue. [updated 2016 Jan 19; cited 2016 Aug 2]. Available from: https://www.cdc.gov/dengue" rel="noopener nofollow noopener" title="External link: https://www.cdc.gov/dengue">https://www.cdc.gov/dengue.
2. 1. World Health Organization Dengue. [cited 2016 Aug 2]. Available from: http://www.who.int/topics/dengue/en" rel="noopener nofollow noopener" title="External link: http://www.who.int/topics/dengue/en">http://www.who.int/topics/dengue/en.
3. 1. Davies WL, Grunert RR, Haff RF, et al. Antiviral activity of 1-adamantanamine (amantadine) Science. 1964;144:862–63. - PubMed
4. 1. Koff WC, Elm JL, Halstead SB. Inhibition of dengue virus replication by amantadine hydrochloride. Antimicrob Agents Chemother. 1980;18(1):125–29. - PMC - PubMed
5. 1. Centers for Disease Control, R.O.C. (Taiwan) As dengue outbreak in Kaohsiung City yet to abate, CECC for Dengue Outbreak continues to provide full support to Kaohsiung City to help bring outbreak under control as soon as possible. 2015. Nov 21, [cited 2016 Jun 8]. Available from: http://www.cdc.gov.tw/english/info.aspx?treeid=bc2d4e89b154059b&nowtre…" rel="noopener nofollow noopener" title="External link: http://www.cdc.gov.tw/english/info.aspx?treeid=bc2d4e89b154059b&nowtre…">http://www.cdc.gov.tw/english/info.aspx?treeid=bc2d4e89b154059b&nowtre….

Show all 10 references 

Publication types

• Comparative Study
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MeSH terms

• Adolescent
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• Adult
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• Aged
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• Amantadine / administration & dosage*
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• Animals
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• Antiviral Agents / administration & dosage*
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• Culicidae
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• Dengue / drug therapy*
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• Dengue / epidemiology
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• Dengue / transmission
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• Female
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• Humans
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• Male
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• Middle Aged
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• Prospective Studies
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• Taiwan / epidemiology
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• Treatment Outcome
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• Young Adult
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Substances

• Antiviral Agents
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• Amantadine
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• PubChem Compound (MeSH Keyword)

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